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Limb salvage versus amputation in patients with osteosarcoma of the extremities: an update in the modern era using the National Cancer Database.

BMC Cancer · 2020 · PMC7557006 · PMID 33054722

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a clear trendno p-value reported
It was interesting to note that although limb salvage was found to be equivalent to amputation in the 1980s, there is a clear trend in the NCDB for more amputations to have been performed closer to the year 2004 (the first year of this study) than to year 2015 (the last year of this study).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.