Inhibition of class I PI3K enhances chaperone-mediated autophagy.

We treated cells depleted of Atg5 with either buparlisib or pictilisib, which produced a small increase in the number of reporter puncta per cell, beyond what was induced by knocking down Atg5 alone; however, this did not reach statistical significance for either drug ( Fig. 4, E and G ).

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