Therapeutic options for the management of severe COVID-19: A rheumatology perspective.

39 showed a trend towards improving mortality with therapeutic PE as an adjuvant treatment in adults with sepsis and multiple organ failure in a controlled clinical trial, while a meta-analysis by Rimmer also showed benefit in adult patient mortality. 40 Addressing this information, Patel et al. 41 used therapeutic PE during the 2009 A (H1N1) influenza epidemic in 3 paediatric patients with a fulminant condition similar to the current pandemic.

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