The fact that the CGI-I did not reach statistical significance, contrary to a study reporting on placebo response in pediatric ASD [ 15 ], may be a random finding or reflect greater weight of caregiver input into CGI scores in autism trials.
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Response to Placebo in Fragile X Syndrome Clinical Trials: An Initial Analysis.
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While not included in the meta-analyses, it is important to note that only the PLS-5 Comp showed borderline significant changes in scores.