Altered Expression Ratio of Actin-Binding Gelsolin Isoforms Is a Novel Hallmark of Mitochondrial OXPHOS Dysfunction.

Densitometric analyses of four independent experiments confirmed a significant increase of GSN levels in whole cells * ( p < 0.05), as well as a highly significant increase in the mitochondrial fractions *** ( p < 0.001) of all mutants relative to control cybrids ( Table 3 ).

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Results from two independent experiments revealed a clear trend towards a decrease in pGSN levels in the secretomes from BCS1L mutant fibroblasts compared to controls ( Figure 3 A).

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