Metformin Suppresses Cancer Stem Cells through AMPK Activation and Inhibition of Protein Prenylation of the Mevalonate Pathway in Colorectal Cancer.

Treatment with mevalonate alone showed a trend toward further tumor growth relative to the control group; the addition of mevalonate to metformin treatment induced a significant increase in tumor growth compared to metformin treatment alone, indicating that mevalonate could reverse the tumor-suppressing effect of metformin ( Figure 4 B–D).

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