Endocrine Resistance in Breast Cancer: The Role of Estrogen Receptor Stability.

Cells · 2020 · PMC7564140 · PMID 32932819

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Indeed, BCa patients with tumours that had nuclear PAK1 expression and phosphorylated ER S305, had significantly reduced responses to tamoxifen; nuclear expression of phosphorylated ER S305 was observed in 36% of patients and showed a trend towards reduced tamoxifen response [ 80 ].

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