Pharmacological Treatment of Mood Disorders and Comorbid Addictions: A Systematic Review and Meta-Analysis: Traitement Pharmacologique des Troubles de L'humeur et des Dépendances Comorbides: Une Revue Systématique et une Méta-Analyse.

This study found, in people with a bipolar spectrum disorder and pathological gambling treated with lithium 900 mg/day, a significant improvement in mania scores (SMD = −0.77) and an improvement in depression scores at a trend significance level (SMD = −0.73). 37 This study was not included in the meta-analysis to reduce heterogeneity of comorbid patient populations, and so the meta-analysis scope was restricted only to alcohol and other substance addiction comorbidities.

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