Although the observed group × time interaction for ACC-Glx was significant, the effect of riluzole in decreasing ACC-Glx in TRS in absolute terms was at a trend significance level ( t = 2.08; p = 0.05).
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patients with FND without pain) were characterized by higher HR at a trend significance level (HR of 84 bpm vs. 80 bpm, t(55) = 1.776, p = 0.081).
Further investigation was performed on the mean deviation from the optimal trajectory which showed a lower deviation in the avatar condition compared to the control condition at a trend significance level ( Z = 1.71 , p = 0.090 ) , but the differences between the no-avatar condition and the control condition or the avatar and the no-avatar condition were not significant ( Z = 1.36 , p = 0.185 ) and ( Z = 0.14 , p = 0.906 ) .
To accommodate the low statistical power due to the small sample size, we also reported results at a trend significance level with a threshold of P <.10.
A Mann-Kendall monotonic trend test was used for dependent variables in a time series with a trend significance level of 10% ( P < .1).
For multivariate analyses, clinico-pathological predictors reaching a trend significance level (p< 0.15) were included into a Cox proportional hazards model using forward and backward analyses.
This study found, in people with a bipolar spectrum disorder and pathological gambling treated with lithium 900 mg/day, a significant improvement in mania scores (SMD = −0.77) and an improvement in depression scores at a trend significance level (SMD = −0.73). 37 This study was not included in the meta-analysis to reduce heterogeneity of comorbid patient populations, and so the meta-analysis scope was restricted only to alcohol and other substance addiction comorbidities.