Isocitrate Dehydrogenase Mutations in Myelodysplastic Syndromes and in Acute Myeloid Leukemias.

At the level of individual co-mutations, the presence of a DNMT3A mutation was significantly associated with complete clinical responses; in line with this finding, patients with co-mutations at the level of genes involved in DNA methylation pathway showed a trend toward achievement of a complete response [ 152 ].

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