Epithelial Ovarian Cancer and the Immune System: Biology, Interactions, Challenges and Potential Advances for Immunotherapy.

J Clin Med · 2020 · PMC7564553 · PMID 32937961

Europe PMC DOI

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0.0510

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failed to reach statistical significancep = 0.051so close (0.05 < p ≤ 0.1)

It was the first oncolytic virus approved for cancer therapy by the FDA (in 2015) to treat advanced melanoma by direct intratumoral injection [ 263 ] after a phase III clinical trial showed a significantly increased durable response rate (≥6 months) compared to GMCSF treatment alone, though with an overall survival rate that failed to reach statistical significance ( p = 0.051) [ 264 ].

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