Through counting the number of both significantly hypo- and hypermethylated CpG dinucleotides mapping to each of these genomic elements, a clear trend emerged: promoters, gene bodies, and regions not mapping to promoters, genes or enhancers (red bars) were highly hypomethylated in insulinomas as compared to beta cells (~90% of CpGs) (red bars in Fig. 1c , Supplementary Data 7 , 8 ).
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Aberrant methylation underlies insulin gene expression in human insulinoma.
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