Metabolic profiling shows pre-existing mitochondrial dysfunction contributes to muscle loss in a model of ICU-acquired weakness.

The cortisol:cortisone ratio was lower in the wasting patients than the non‐wasting patients on Days 3 and 7 ( P = 0.043 and P = 0.016, respectively) whereas although the tetrahydrocortisone:cortisone ratio was higher in wasting patients than non‐wasting patients on Days 1 and 3, these differences did not reach statistical significance ( Figure 3 ).

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