showed a trendp = 0.07
Treatment of polarized ARPE-19 cells with 100 nM ZK for 3 h showed a trend (p = 0.07) to increase BECN1 expression in low autophagy-/UPR-related gene-expressing cells (Fig. 6 c) but significantly decreased BECN1, MAP1LC3B, mTOR, ATF6, DDIT3, EIF2AK3 and HSPA5 expression (Fig. 6 a,c,d,f,j,k,m) in high autophagy-/UPR-related gene-expressing cells.