Imbalance of laminar-specific excitatory and inhibitory circuits of the orbitofrontal cortex in autism.

Importantly, we found robust differences between Control and ASD groups, suggesting that differences between the two groups would remain highly significant with the addition of more subjects in future studies.

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Overall, neurons in the ASD group showed a trend for higher relative ratio of inhibitory/total neurons compared with the control group however, no significant difference was found (Fig. 8 h–j; PV: p = 0.528, CB: p = 0.053, CR: p = 0.391; ANOVA).

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