Integrative analysis identifies the association between <i>CASZ1</i> methylation and ischemic stroke.

After adjusted for covariates, the associations between methylation levels of 8 sites and IS were nominally significant, and the associations between methylation levels of CASZ1_70 (adjusted OR = 0.99 [0.98–1.00]; p = 7.26 × 10 −4 ) and CASZ1_67 (adjusted OR = 0.98 [0.98–0.99]; p = 5.54 × 10 −5 ) and IS were significant.

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Among them, p values of 28 CpG sites in 12 loci (14 genes) exceed 1 × 10 −5 ( figure 1 ) and 10 of them could be considered significant ( P SMR < 5.67 × 10 −7 , Bonferroni correction).

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