Integrated proteomics reveals brain-based cerebrospinal fluid biomarkers in asymptomatic and symptomatic Alzheimer's disease.

Sci Adv · 2020 · PMC7577712 · PMID 33087358

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.0600

boldest claim

The sentences

highly significantP = 1.54 × 10 −10actually significant

However, we also identified other highly significant targets, such as GDP dissociation inhibitor 1 (GDI1; P = 1.54 × 10 −10 ) and SPARC-related modular calcium binding 1 (SMOC1; P = 6.93 × 10 −9 ).

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approached significanceP = 0.06so close (0.05 < p ≤ 0.1)

This analysis revealed a total of 14 brain modules with statistically significant overlap in the discovery CSF dataset (FDR-corrected P < 0.05), as well as one additional module (M18) whose extent of overlap approached significance (FDR-corrected P = 0.06) ( Fig. 4C , top row).

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