DNA hypomethylation of the Krüppel-like factor 11 (KLF11) gene promoter: a putative biomarker of depression comorbidity in panic disorder and of non-anxious depression?

Sample 2 Significant differences in KLF11 DNA methylation were observed between MDD patients with and without anxious depression at CpG site 1 ( p = 0.041) and, on a nominally significant level, with regard to average methylation ( p = 0.052) and methylation at CpG sites 2–4 ( p = 0.053-0.081; see Table 3 ; Fig. 3 ), with patients with non-anxious depression showing decreased KLF11 methylation.

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