Association of Uncommon, Noncoding Variants in the APOE Region With Risk of Alzheimer Disease in Adults of European Ancestry.

JAMA Netw Open · 2020 · PMC7582128 · PMID 33090224

Europe PMC DOI

hedged sentence

0.0470

closest p · 0.9× alpha

0.0470

boldest claim

The sentences

nominally significantP = .047actually significant

failed to reach significanceP = .07so close (0.05 < p ≤ 0.1)

The association between rs2075650 and AD was nominally significant among ε4 homozygotes (model 4) (OR, 1.33; 95% CI, 1.00-1.77; P = .047) but failed to reach significance after APOE adjustment (model 2; OR, 1.09; 95% CI, 0.99-1.19; P = .07) or among ε3 homozygotes (model 3; OR, 1.16; 95% CI, 0.98-1.38; P = .09).

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