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ND-13, a DJ-1-Derived Peptide, Attenuates the Renal Expression of Fibrotic and Inflammatory Markers Associated with Unilateral Ureter Obstruction.

Int J Mol Sci · 2020 · PMC7582723 · PMID 32987947

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ND-13 Treatment Attenuates the UUO-Induced Cortical Macrophage Inflammation in WT Mice, but not in DJ-1 −/− Mice, While not Preventing the Infiltration of T-Lymphocytes in Either Genotype As expected, the population of T-lymphocytes (CD3 + cells) in the cortex was elevated in WT mice after UUO, although it did not reach statistical significance from the levels shown in mice that underwent sham surgery (sham vs.

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