Association of circulating long non-coding RNA MALAT1 in diagnosis, disease surveillance, and prognosis of acute ischemic stroke.

Discussion Our results indicated that: 1) lnc-MALAT1 expression was decreased in AIS patients compared to controls, and it had a close correlation with AIS; 2) lnc-MALAT1 high expression was correlated with decreased NIHSS score as well as reduced inflammatory factors levels in AIS patients; and 3) lnc-MALAT1 high expression showed a trend for prolonged RFS compared to lnc-MALAT1 low expression in AIS patients, but without statistical significance. lncRNAs are involved in a variety of biological processes (such as gene transcription, organizing RNA-protein complex, and management in protein activity) ( 16 – 19 ).

also in 53,322 other papers