The DNA methylome of human sperm is distinct from blood with little evidence for tissue-consistent obesity associations.

PLoS Genet · 2020 · PMC7584170 · PMID 33048947

Europe PMC DOI

hedged sentence

0.0280

closest p · 0.6× alpha

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boldest claim

The sentences

nominally significantP = 0.028actually significant

Out of the nine probes at which Noor and colleagues found an association between cord blood DNA methylation and paternal periconceptional BMI, only one showed a nominally significant association in consistent effect direction in the sperm obesity EWAS ( P = 0.028, DNA methylation difference = 6%) and the combined mixed effects model in blood and sperm ( P = 0.01, DNA methylation difference = 4%).

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