Neddylation blockade induces HIF-1α driven cancer cell migration via upregulation of ZEB1.

Sci Rep · 2020 · PMC7585416 · PMID 33097763

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a decreasing trendno p-value reported

Since the data from lung tumor samples showed a decreasing trend in NEDD8 mRNA expression, and considering the possible error resulting from human data collection and small sample sizes, we verified the molecular mechanism involved in cell migration and neddylation in vitro through prostate (PC3), lung (H1299), ovarian (SKOV3) derived cancer cell lines.

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showed a trendno p-value reported

We found that HIF-1α expression showed a trend towards attenuation similar to that of ZEB1 (Fig. 4 e,f).

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