MEPE loss-of-function variant associates with decreased bone mineral density and increased fracture risk.

The nominally significant association signal at this lead variant (rs11934731, effect size for the minor allele = 0.029 SD, P -value = 0.01, MAF = 33%) was slightly attenuated when we performed conditional analysis with MEPE p.Lys70IlefsTer26 as a covariate in the model (effect size conditional = 0.021 SD, P -value conditional = 0.06; Supplementary Fig. 1 , Supplementary Data 1 ).

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Additionally, the association for the MEPE LoF variant remains highly significant when conditioning for the lead variant of the eBMD analysis (effect size conditional = −0.529 SD, P -value conditional = 5.3 × 10 −18 ).

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