Molecular Analysis of Fetal and Adult Primary Human Liver Sinusoidal Endothelial Cells: A Comparison to Other Endothelial Cells.

Corr = 0.50, p < 2.2 × 10 −16 ) LSECs with periportal LSECs, whereas a negative trend and a non-significant correlation was found for central venous LSECs in both MacParland et al. and Aizarani et al. reported LSECs ( Supplementary Figure S1 ).

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Correlation between Illumina EPIC arrays and QIASeq Methyl WGBS showed an expected highly significant correlation of above 90% for both LSECs (adult and fetal) ( Figure 3 C).

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Observing in more detail the pathway activation scores in Figure 1 G, we found that only the EIF2 pathway was strongly inhibited in f-LSECs (Z score below 2 in all comparisons), whereas ATM signaling showed a borderline significant Z score, indicating activation in f-LSECs. 2.4.

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