Three distinct mechanisms, Notch instructive, permissive, and independent, regulate the expression of two different pericardial genes to specify cardiac cell subtypes.

Note that the fact that considerable reduction in gene product levels of the relevant genes is detected with knockdowns while using RNA from whole embryos despite the knockdown occurring in only a minute subset of embryonic cells (the cardiac mesoderm) indicates that the RNAi-induced knockdown in the cardiac mesoderm is quite significant.

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