Renal and Cardiovascular Effects of SGLT2 Inhibition in Combination With Loop Diuretics in Patients With Type 2 Diabetes and Chronic Heart Failure: The RECEDE-CHF Trial.

Circulation · 2020 · PMC7594536 · PMID 32865004

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did not reach statistical significanceP =0.10so close (0.05 < p ≤ 0.1)

At week 6, patients taking empagliflozin had an increased FENa in the hour after administration of loop diuretic compared with when taking placebo, but again this did not reach statistical significance (mean difference, 2.51% [95% CI, −0.27 to 5.28]; P =0.10).

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