Intratumoral injection reduces toxicity and antibody-mediated neutralization of immunocytokine in a mouse melanoma model.

J Immunother Cancer · 2020 · PMC7594540 · PMID 33115944

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did not reach statistical significanceno p-value reported

Importantly, MAHA + mice showed lower serum IC levels than the MAHA − mice, when the IC was injected intratumorally (p=0.02) and when the IC was injected intravenously (p=0.11), though the intravenous comparison did not reach statistical significance likely due to small sample size ( online supplemental figure 3 ).

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