Instrumental activities of daily living, amyloid, and cognition in cognitively normal older adults screening for the A4 Study.

17 Another recent smaller longitudinal study using the ADCS ADL‐PI and florbetapir PET followed 269 non‐demented participants (59% with global Clinical Dementia Rating [CDR] = 0 [equivalent to CN] and 41% with global CDR = 0.5 [equivalent to MCI]) over 3 years and showed a trend for an association between worsening IADL performance in amyloid‐positive compared to amyloid‐negative participants; looking at the groups separately, the amyloid‐positive participants remained stable in their IADL, while the amyloid‐negative participants improved. 16 Thus, our analyses and these two studies support the notion that there is a relationship between IADL difficulties and amyloid burden even in CN older adults.

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