proposed a spatial immuno-oncology index based on TIL and macrophages proximity analysis to tumor buds to provide highly significant combinatorial risk model for stage II CRC patient stratification [ 31 , 32 ].
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Immuno-Interface Score to Predict Outcome in Colorectal Cancer Independent of Microsatellite Instability Status.
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The univariate Immunogradient-based OS stratifications were similar in the subgroups of MSS and MSI tumors ( Figure 1 B,C,F), except for CM for CD20+ cell density which did not reach statistical significance ( Figure 1 E).