Polymorphisms within Immune Regulatory Pathways Predict Cetuximab Efficacy and Survival in Metastatic Colorectal Cancer Patients.

Cancers (Basel) · 2020 · PMC7601940 · PMID 33065994

Europe PMC DOI

hedged sentences

0.0490

closest p · 1.0× alpha

0.0490

boldest claim

The sentences

borderline significancep = 0.049actually significant

41.1+ months for C/C genotype; univariate HR 2.18, 95% CI 0.98–4.85), though with borderline significance ( p = 0.049).

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did not reach statistical significanceno p-value reported

In the FIRE-3 validation cohort, patients with an IDO1 rs3739319 A allele had a numerically longer OS (33.1 months) in univariate (HR 0.72, 95% CI: 0.50–1.03, p = 0.068) and multivariate (HR 0.70, 95% CI: 0.48–1.02, p = 0.063) analyses, though this association did not reach statistical significance ( Table 3 ).

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