Obesity Augments Glucocorticoid-Dependent Muscle Atrophy in Male C57BL/6J Mice.

After one week of dexamethasone treatment, we observed induction of Foxo3 and the atrogenes, Trim63 (Atrogin-1) and Fbxo32 (MuRF1), to be greater in obese mice compared to their lean counterparts, though the interaction between obesity status and dexamethasone treatment did not reach statistical significance for these transcripts ( Figure 3 ).

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Similarly, the cross-sectional area of the muscle was reduced 13% in the NCD group and 23% in the HFD group, though the modifying effect of obesity did not quite reach statistical significance ( p interaction = 0.11).

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