When comparing percent change in weight and fat mass with baseline variables to identify potential predictive biomarkers, one MS peak was marginally significant in the full analysis, α-aminoadipate (R 2 = 0.29, p = 0.0007).
Metabolite values were analyzed in both baseline plasma samples and samples collected following the six-month dietary intervention to consider both metabolites that could predict the response to diet and those that changed in response to diet or weight loss.Eight metabolites changed over the intervention at a nominally significant level: D-pantothenic acid, L-methionine, nicotinate, aniline, melatonin, deoxycarnitine, 6-deoxy-L-galactose, and 10-hydroxydecanoate.