Can Intraoperative Low-Dose <i>R</i>,<i>S</i>-Ketamine Prevent Depressive Symptoms After Surgery? The First Meta-Analysis of Clinical Trials.

Front Pharmacol · 2020 · PMC7604489 · PMID 33192527

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may not be significantno p-value reported

However, this effect may not be significant in patients with severe pain.

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did not reach statistical significanceno p-value reported

The primary outcome measure, a change in Montgomery-Asberg Depression Rating Scale scores from baseline to day 28, did not reach statistical significance, and subgroup analysis based on age showed poorer improvement in ≥75 age-group than younger age-groups ( Ochs-Ross et al., 2020 ), indicating S-ketamine may not be an effective antidepressant in elderly population.

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