In comparison with the control fibroblasts, DC fibroblasts showed a slight trend toward increased NMNAT‐1 and NMNAT‐2 expression, but no substantial change in NMNAT‐3 and NAMPT (Fig 1 D and E).
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Re-equilibration of imbalanced NAD metabolism ameliorates the impact of telomere dysfunction.
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We noted a slight decrease in total γH2AX foci in DC fibroblasts with NR treatment, but it did not reach statistical significance (data not shown).