Barely Significant
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Opicapone Efficacy and Tolerability in Parkinson's Disease Patients Reporting Insufficient Benefit/Failure of Entacapone.

Mov Disord Clin Pract · 2020 · PMC7604656 · PMID 33163567

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The subgroup entacapone failures were more than 2.3 times more likely to discontinue opicapone than the entacapone switchers subgroup but this failed to reach statistical significance in multivariate analysis.

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