In addition, the T cell markers Cd3g and Cd8a showed a trend towards higher expression in NRF2 knockout tumors (Supplementary Fig. 7B ) and quantification of CD3 + immune cell infiltration into control and NRF2 knockout melanomas showed a similar trend (Supplementary Fig. 7C, D ).
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The transcription factor NRF2 enhances melanoma malignancy by blocking differentiation and inducing COX2 expression.
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