Peptidylarginine deiminase 2 has potential as both a biomarker and therapeutic target of sepsis.

Pad2 –/– significantly reduced CLP-induced permeability in lung and kidney, and it showed a trend toward the decreased permeability in spleen and liver ( Figure 4A ), suggesting that KO of the Pad2 gene could ameliorate sepsis-induced organ dysfunction by reducing microvascular permeability.

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