Specifically bound BZIP transcription factors modulate DNA supercoiling transitions.

Moreover, the observed doubled torsional rigidity of MafB-bound MARE-DNA, we believe, is a local effect created by the protein, however highlighting an important trend that a specifically bound protein can inhibit the propagation of supercoiling thus likely leading to the accumulation of supercoiling at the flanking sites of MARE rather than within the TF-bound region, which can contribute to the regulation of transcription of near-located genes.

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