Glucocorticoid-dependent transcription in skin requires epidermal expression of the glucocorticoid receptor and is modulated by the mineralocorticoid receptor.

Consistent with the results in cultured keratinocytes, Igfl3 and Tfcp2l1 showed a trend towards decreased induction in the epidermis of MR EKO relative to CO (Fig. 6 a,b).

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There was an overall trend towards strong repression of these genes in the epidermis and dermis of MR EKO vs CO mice; however, there were no statistically significant differences among genotypes (Fig. 6 c,d).

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