Developing and testing high-efficacy patient subgroups within a clinical trial using risk scores.

To illustrate the broader applicability of the method, we have applied it to the data from START randomized controlled trial.We showed that theCVRSmethod applied with an additional selection step, identified a sensitive group that conferred a nominally significant interaction effect ( P <.05) between the treatment and the sensitivity status, in the case where there was no overall significant treatment effect.

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