The Genomic Landscape of Early-Stage Ovarian High-Grade Serous Carcinoma.

Overall, in the ILR analysis, there was a highly significant difference between cohorts (generalized Wald test; P = 7.234e−10), with greater signature 3 exposure in the early-stage cohort and more signature 4 in the late-stage cohort ( Fig. 4C ).

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The clusters were prognostic, with a significant trend for reduced survival across the clusters ( Fig. 5D ), which remained significant by Cox proportional hazards ( Fig. 5E ).

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