Rhythmicity of intestinal IgA responses confers oscillatory commensal microbiota mutualism.

2H ), although in some cases the magnitude of this difference was altered or did not reach statistical significance.

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To further investigate the nature of diurnal regulation of IgA + PC responses, we sort purified small-intestinal IgA + PCs at ZT0, 6, 12 and 18 and performed bulk RNA-seq; of ~16,000 transcripts detected within our samples 2713 genes were found to exhibit highly significant time of day differences and oscillatory patterns after adjusting for false discovery rate (JTK analysis, BHQ <0.01), equivalent to ~16% of the observed transcriptome ( Fig. 1E , Fig.

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