Bone Morphogenetic Protein Pathway Antagonism by Grem1 Regulates Epithelial Cell Fate in Intestinal Regeneration.

Molecular and morphologic phenotyping of the animals showed a reduction in intestinal Lgr5 expression and crypt base columnar (CBC) cell number in the epithelium 17 ( Figure 1A and B ). There was subtle variation in the stromal and immune cell landscapes between mice, but this did not reach statistical significance on cell quantification, except for fewer macrophages and Cd8 cells in Vil1-Cre ; Rosa26 Bmp4 small intestine ( Figure 1C , Supplementary Figure 1 ).

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