Sustained meningeal lymphatic vessel atrophy or expansion does not alter Alzheimer's disease-related amyloid pathology.

Instead, the APdE9;K14-sR3 mice showed a trend for lower Aβ load in the hippocampus, as evidenced by immunohistochemistry (IHC) and enzyme-linked immunosorbent assay (ELISA) (individual t -tests P > 0.05; P = 0.03 in two-way analysis of variance (ANOVA); Extended Data Fig. 2c–e ).

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