Elevated serum interferon-α2 associates with activity and flare risk in juvenile-onset systemic lupus erythematosus.

Patients with active or intermediate disease activity (serving as reference group) displayed numerically higher median serum IFN-α2 levels (median 1583 fg/ml, IQR 100–7850), compared with patients in LDAS (median 228 fg/ml, IQR 3–1278) or remission (median 11 fg/ml, IQR 3–291), though these reductions did not reach statistical significance ( P = 0.099 for LDAS; P = 0.089 for remission) ( Supplementary Table 10 , available at Rheumatology online).

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