The Balance of Stromal BMP Signaling Mediated by GREM1 and ISLR Drives Colorectal Carcinogenesis.

Gastroenterology · 2021 · PMC7617122 · PMID 33197448

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The GREM1-neutralizing antibody–treated group showed a trend toward prolonged overall survival and a trend toward decreased tumor growth, although the groups, as dosed in this study, did not show significant differences in survival ( Supplementary Figure 20E and F ).

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