Coevolution of Atypical BRAF and KRAS Mutations in Colorectal Tumorigenesis.

Mol Cancer Res · 2025 · PMC7617415 · PMID 39751654

Europe PMC DOI

hedged sentences

0.0130

closest p · 0.3× alpha

0.0600

boldest claim

The sentences

nominally significantP = 0.013actually significant

Separate analyses of class 2 and 3 mutations independently showed nominally significant positive selection of BRAF in MSS tumors for both classes (dN/dS = 7.21; P = 0.013 and dN/dS = 8.51; P = 0.005, respectively).

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borderline significantP = 0.06so close (0.05 < p ≤ 0.1)

There was also a borderline significant difference observed between class 2 and class 3 BRAF -mutant colorectal cancers (frequencies 16.1% and 35.8%, respectively; P = 0.06, Fisher exact test; Table 1 ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.