Novel genetic variants in tuberculosis-associated immune reconstitution inflammatory syndrome.

Am J Respir Crit Care Med · 2026 · PMC7618894 · PMID 41738202

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nominally significantno p-value reported

Over-representation analysis of all 1,980 nominally significant variants revealed that TB-IRIS risk variants were significantly enriched in pathways including B cell receptor activation, FcγR-dependent phagocytosis, IFN-γ signalling, and neutrophil degranulation, while protective variants were associated with heme biosynthesis, IL-10 synthesis, and class I MHC pathways ( Figure 1B ).

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