Rare variants in pharmacogenes influence clozapine metabolism in individuals with schizophrenia.

Eur Neuropsychopharmacol · 2024 · PMC7619122 · PMID 38310750

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0.0090

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0.0090

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nominally significantP = 0.009actually significant

We observed that rare damaging variants in CYP1A2 displayed the strongest nominally significant associations with higher clozapine (β = 0.324, SE = 0.124, P = 0.009, R 2 = 0.233 %) and norclozapine (β = 0.320, SE = 0.115, P = 0.005, R 2 = 0.235 %) concentrations.

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